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Citation information in Europe Pubmed Central

BACKGROUND: Virus inactivation procedures are used to prevent contamination of plasma-derived blood products with viruses. Pasteurization or prolonged dry heat has proven effective against several enveloped and nonenveloped viruses and provides an additional layer of safety for plasma products. STUDY DESIGN AND METHODS: The resistance of porcine circovirus 2 (PCV2) and chicken anemia virus (CAV), two small, nonenveloped viruses, to standard (pasteurization, 10 hr at 60 degrees C; dry heating, 80 degrees C for 72 hr) and more extreme heat inactivation procedures (temperatures up to 120 degrees C) was determined. The ability of these procedures to inactivate PCV2 and CAV was measured by comparison of in vitro infectivity before and after treatment. RESULTS: Infectivity of PCV2 and CAV was reduced by approximately 1.6 and 1.4 log by pasteurization and by 0.75 and 1.25 log by dry-heat treatment, both substantially more resistant than other viruses previously investigated. PCV2 and CAV were additionally almost completely resistant to dry-heat treatment up to 120 degrees C for 30 minutes (mean log infectivity reductions, 1.25 and 0.6), although both were more effectively inactivated when the temperature of wet-heat treatment was increased to 80 degrees C (>3.2 and >3.6 log infectivity reduction). CONCLUSION: Although neither PCV2 nor CAV are known to infect humans, their inactivation properties may represent those of other small DNA viruses known to be present (e.g., TT virus, small anellovirus) or potentially present in human plasma. Findings of extreme thermal resistance demonstrate that recipients of plasma-derived therapeutics may potentially still be exposed to small DNA viruses, despite the implementation of viral inactivation steps.

Citation information in Europe Pubmed Central

Picornaviridae are a large virus family causing widespread, often pathogenic infections in humans and other mammals. Picornaviruses are genetically and antigenically highly diverse, with evidence for complex evolutionary histories in which recombination plays a major part. To investigate the nature of recombination and selection processes underlying the evolution of serotypes within different picornavirus genera, large-scale analysis of recombination frequencies and sites, segregation by serotype within each genus, and sequence selection and composition was performed, and results were compared with those for other nonenveloped positive-stranded viruses (astroviruses and human noroviruses) and with flavivirus and alphavirus control groups. Enteroviruses, aphthoviruses, and teschoviruses showed phylogenetic segregation by serotype only in the structural region; lack of segregation elsewhere was attributable to extensive interserotype recombination. Nonsegregating viruses also showed several characteristic sequence divergence and composition differences between genome regions that were absent from segregating virus control groups, such as much greater amino acid sequence divergence in the structural region, markedly elevated ratios of nonsynonymous-to-synonymous substitutions, and differences in codon usage. These properties were shared with other picornavirus genera, such as the parechoviruses and erboviruses. The nonenveloped astroviruses and noroviruses similarly showed high frequencies of recombination, evidence for positive selection, and differential codon use in the capsid region, implying similar underlying evolutionary mechanisms and pressures driving serotype differentiation. This process was distinct from more-recent sequence evolution generating diversity within picornavirus serotypes, in which neutral or purifying selection was prominent. Overall, this study identifies common themes in the diversification process generating picornavirus serotypes that contribute to understanding of their evolution and pathogenicity.

Organize Your Family:

Having a clean home and structured family life can have lasting positive effects on your children. Parents who keep their homes clean are more efficient and organized, which can over into their children’s habits.

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that the cleanliness of the homes children grow up in can predict their educational attainment and future earnings. Over several years, interviewers visited subjects homes and rated overall cleanliness on a five-point scale. 25 years later, researchers assessed the education level and earnings of the young adults who lived in those homes.

Out of the 3,395 young adults studied, the ones with the cleanest homes had attained more education and earned more money, as a pattern. There are small hacks you can do to keep your life and the lives of your children organized.

Organize Your Meals:

Having an organized kitchen and meal plan is linked to better food variety, diet quality and a lower body weight. In a study from the International Journal of Behavioral Nutrition and Physical Activity, those who planned meals were less likely to be overweight and obese. They were also shown to have a healthier diet.

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that eating out of the home is a risk factor for higher calorie and fat intake, as well as lower micronutrient intake. S tudies have linked eating out frequently with the risk of becoming overweight.

Planning to cook your meals at home using fresh, quality ingredients can add benefit to and even lengthen your life. Here are some easy tricks to weave into your daily life:

Organize Your Social Life:

Organizing your social life can not only help you make time for everyone who you care about but can lead to an overall feeling of satisfaction. The Department of Sociology at the University of North Carolina reports that taking time for social interaction relates to better physiological functioning and lower risk of physical disorders.

Conversely, having an unorganized life and cluttered spaces can lead to social isolation. Isolation has been shown to lead to disrupted sleep patterns, weakened immune systems, and higher levels of the stress hormone. Another study found that social isolation can lead to a greater risk of heart failure.

Researchers at The University of Texas found that fostering strong relationships with friends, family and significant others leads to better health and a longer life . Here are some small ways to organize your social life and nurture relationships:

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Superintendent of Schools

Marco Pochintesta

Welcome to the Pearl River School District. As Superintendent of Schools, it has been an honor to lead this district over the last three years. Together, as a school community, we have accomplished much to support our district mission, Every Child Can and Will Learn. From supporting our youngest students with the implementation of full-day kindergarten, to adding new electives at the high school, including Robotics, Computer Science, and Women in History, we continue our focus ofdeveloping students'21st century skills, critical thinking, creative problem solving, communication and collaboration that our students need today and in the future.

While we have made strides, there is more to be done. We will continue to evaluate our programs for students at all levels. We look forward to the opportunities for teaching and learning as our capital improvement projects move from design to construction and completion.

Thank you for your continued support of our students and school community.

Marco F. Pochintesta Superintendent of SchoolsPearl River School District135 West Crooked Hill RoadPearl River, NY 10965 (845) 620-3922 FitFlop Womens Uberknit Ballerina with BowMetallic Closed Toe Ballet Flats Discount 2018 New Cheap Discount Sale uMSyYnvF5
, Secretary (845) 620-3922(834) 620-3927 (fax)

Mr.Pochintesta joined the Pearl River School District in2014. As superintendent, he reports to the Board of Education and manages the district's400 faculty and staff members. When he is not in one of the district schools, you can find him in the district administrative offices.

Education : Doctoral Studies in Education, Manhattanville College (in progress)M.S.in Administration and Supervision, College of New RochelleM.A. in Social StudiesEducation,Lehman CollegeB.A. in Political Science,Fordham University

Experience : 2013-2014: Superintendent of Schools, Wappingers Central School District2012-2013: Interim Superintendent of Schools, Wappingers Central School District2010-2012: Assistant Superintendentfor Administration, Wappingers Central School District2008-2010: Principal, John Jay Senior High School,Wappingers Central School District2005-2008: House Principal,Arlington High School, Arlington CentralSchool District2002-2005: Principal, La Salle Academy; NYC1993-2002: Assistant Principal for Student Affairs, LaSalle Academy, NYC1990-1993: Social Studies Teacher, IS144 Bronx, NY1988-1990: Italian Teacher, St. Raymond's High School, Bronx, NY

Professional Affiliations : New York State Council of School Superintendents Lower Hudson Council of School Superintendents, TreasurerMid-Hudson School Study Council, Executive CommitteeTri-States Consortium Superintendents Study Group

Pearl River School District

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Welcome to the memorial page for February 17, 1937 ~ June 3, 2017 (age 80)
Welcome to the memorial page for

Darreld D. Bjorklund

February 17, 1937 ~ June 3, 2017 (age 80)
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Darreld D. Bjorklund, age 80, of Albert City, Iowa, died on Saturday, June 3, 2017, at the Good Samaritan Center in Manson, Iowa.

Funeral services will be held Thursday, June 8, 2017, at 10:00 a.m. at the United Pentecostal Church in Marathon, Iowa. Burial will be in the Fairfield Township Cemetery in Albert City. Visitation will take place Wednesday, June 7, 2017, from 5-7:00 p.m. at the Sliefert Funeral Home in Albert City.The Sliefert Funeral Home in Albert City is in charge of arrangements.

Darreld Dewayne Bjorklund, the son of Wayne and Vera (Martin) Bjorklund was born in Albert City, Iowa on February 17, 1937. He lived his youth in the Albert City community and attended Albert City High. He continued his education at Western Iowa Tech where he received training as an electrician.

Darreld was united in marriage to Bettie Witham on June 23, 1956, at the Presbyterian Church in Fonda, Iowa, and to this union eight children were born: Dan, Randy, Rhonda, Duane, Kim, James, Mindy, and Tina. Darreld was confirmed at the Mission Covenant Pentecostal Church in Marathon in 1952, and he was baptized there in 1959. For the first few years of their marriage, Bettie and Darreld lived near Albert City, Iowa. However, the majority of the married lifetime was spent in Storm Lake, Iowa. Darreld owned and operated a vacuum cleaner and sewing business. In 1998, they came to make their home in Albert City, where they resided since.

Darreld was a member of the United Pentecostal Church in Marathon, where he had served as a trustee. Darreld’s children, grandchildren and great grandchildren were the pride and joy of his life, and he cherished the time he could spend with them and the memories they created. Darreld also enjoyed attending church, fishing, playing cribbage, gardening and sports, especially his Chicago Cubs.

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